Cognitive impairment (CI) may occur in up to 65% of multiple sclerosis (MS) patients. The aim of the longitudinal multi-dimensional multiple sclerosis study is to determine the factors that result in cognitive impairment in MS. Each year, data are collected from MS patients across a variety of dimensions, such as psychological, neurological, electrophysiological, and radiological.
Dimensions
Psychology
Neurology
Electrophysiology
- P3a and P3b, VESPA
Radiology
- MRI data are acquired on the St. Vincent's University Hospital 1.5 T scanner. Proton Density, T2, high-resolution T1, and double inversion scans are acquired.
People
Trinity College Dublin
- Dr Robert Whelan. Dr Whelan is the lead scientist on this project.
- Hanni Kiiski (PhD candidate, IRCSET funded)
- Hugh Nolan (PhD candidate, IRCSET funded)
- Prof. Richard Reilly (PI)
- Stephen (DTI)
- Ed (Vespa)
University College Dublin
- MC,Sean,JB
SVUH
Prof T,Siobhan K,RL, JOS
Journal Publications
- R. Whelan, R. Lonergan, H. Kiiski, H. Nolan, K. Kinsella, M. Hutchinson, N. Tubridy, R.B. Reilly. Impaired information processing speed and attention allocation in multiple sclerosis patients versus controls: A high-density EEG study. Journal of the Neurological Sciences. E-pub ahead of print
- R. Whelan, R. Lonergan, H. Kiiski, H. Nolan, K. Kinsella, J. Bramham, M. O'Brien, R.B. Reilly, M. Hutchinson, N. Tubridy. A high-density ERP study reveals latency, amplitude, and topographical differences in multiple sclerosis patients versus controls. Clinical Neurophysiology. E-pub ahead of print.
Conference Publications
- E.C. Lalor, R. Lonergan, H. Kiiski, K. Kinsella, R.B. Reilly, M. Hutchinson, N. Tubridy, R. Whelan. (2009). A method for the rapid assessment of visual processing latencies in multiple sclerosis, Irish Journal of Medical Science, 179, 3, S123.
- R. Whelan, R. Lonergan, H. Kiiski, H. Nolan, K. Kinsella, J.Bramham, M.C. O’Brien, R.B. Reilly, M. Hutchinson, N. Tubridy. (2009). ERP abnormalities in multiple sclerosis patients: A high-density EEG study, Irish Journal Of Medical Science, 179, 3, S106.
- H. Kiiski R., Lonergan, R. Whelan, H. Nolan, K. Kinsella, M. O’Brien, R.B. Reilly, M. Hutchinson, N. Tubridy. (2009). P3 abnormalities in multiple sclerosis as a function of oligoadenylate synthetase genotype, Irish Journal Of Medical Science, 179, 3, S123.
- Whelan, R., Lonergan, R., Killane, I., Reilly, R.B., Hutchinson, M., & Tubridy, N. (2008). Cognitive impairment in multiple sclerosis correlates highly with a delayed P3 component in event-related potential testing. Multiple Sclerosis, 14, S267.