Skip to main content »

Trinity College Dublin

Daniel J. Kelly, B.A., B.A.I., M.Sc., Ph.D., F.T.C.D.

Professor (School of Engineering)

Tel: +353 1 8963947
Fax: +353 1 6795554
Email: kellyd9@tcd.ie

BIOGRAPHY

Dr Daniel Kelly is a Professor in the School of Engineering in Trinity College Dublin and Director of the Trinity Centre for Bioengineering (TCBE). He is also one of the founding Principal Investigators of AMBER, a new Advanced Materials and Bioengineering research centre based in Trinity College Dublin. The aim of the TCBE is to promote and facilitate research and education in Bioengineering and related disciplines, and to ensure this research finds its way into the clinic in order to improve patient care. Dr. Kelly leads a large multidisciplinary orthopaedic tissue engineering group based in the Centre. The goal of his lab is to understand how environmental factors regulate the fate of adult stem cells. This research underpins a more translational programme aimed at developing novel biomaterial and mesenchymal stem cell (MSC) based therapies to regenerate damaged and diseased orthopaedic tissues such as articular cartilage and bone.

RESEARCH AREAS

Articular cartilage tissue engineering: Dr. Kelly’s lab is pioneering the use of adult stem cells isolated from synovial joints such as the knee, combined with bioreactors to mechanically stimulate these cells, to tissue engineer functional cartilage grafts. They have recently demonstrated that it is possible to engineer zonally organised tissues such as articular cartilage by recapitulating the gradients in regulatory signals that during development and skeletal maturation are believed to drive spatial changes in stem cell differentiation and tissue organization. They are also developing single stage therapies for articular cartilage regeneration that combine biomimetic scaffolds with freshly isolated stromal cells sourced from patients in-clinic.

Bone, joint and limb regeneration: Dr. Kelly’s lab have also demonstrated how complex tissues, such as the bone-cartilage interface, can be regenerated by designing tissue engineering strategies that recapitulate aspects of the normal long bone developmental process. They have also been able to scale-up this process to tissue engineer entire new bones. They are currently extending this strategy to tissue engineer whole joints using adult stem cells and 3D bioprinting.

Stem cell mechanobiology: Dr. Kelly’s lab is investigating how extrinsic mechanical cues can regulate stem cell fate. His lab has also identified novel roles for both mechanical signals and oxygen in regulating chondrogenesis and hypertrophy of MSCs.

AWARDS AND FUNDING

Prof Kelly has secured over €8 million in funding as a Principal Investigator. In 2008 he was the sole recipient of Science Foundation Ireland’s President of Ireland Young Researcher Award (PIYRA). The PIYRA is Science Foundation Ireland’s most prestigious award. In 2009 he received a Fulbright Award to take a position as a Visiting Research Scholar at the Department of Biomedical Engineering in Columbia University, New York. In 2010 he was awarded a European Research Council (ERC) starter grant of €1.5 million to develop novel stem cell based therapies to regenerate damaged articular cartilage. In 2013 he was awarded a €1.7m Principal Investigator grant from Science Foundation Ireland to develop novel tissue engineering approaches to treat degenerative joint disease. He was recently awarded an ERC consolidator grant of €2,000,000, making him one of the few PIs to have received two such awards from the European Research Council. A study from his lab received the 2012 Perren Award of the European Society of Biomechanics for best scientific paper.

PUBLICATIONS

An up-to-date list of lab papers and citations is available at http://scholar.google.com/citations?user=hdwHS_gAAAAJ&hl=en

In total, Dr. Kelly has authored or co-authored over 95 peer reviewed journal papers. His h-index is currently 32 and his i10-index is 63.

JOURNAL PUBLICATIONS:

1. Cunniffe, G.M., Vinardell, T., Murphy, M.J., Thompson, E.M., Matsiko, A., O’Brien, F.J., Kelly, D.J. Porous decellularized tissue engineered hypertrophic cartilage as a scaffold for large bone defect healing. Acta Biomaterilia (in press). 2. Mesallati, T., Buckley, C.T., Kelly, D.J. Engineering cartilaginous grafts using chondrocyte-laden hydrogels supported by a superficial layer of stem cells. Journal of Tissue Engineering and Regenerative Medicine (in press). 3. Sridharan, R, Cameron, A.R., Kelly, D.J., Kearney, C.J., O’Brien, F.J., Biomaterial based modulation of macrophage polarization: a review and suggested design principles. Materials Today, Vol 18 (6), 313-325, 2015. 4. Sheehy, E.S, Mesallati, T., Kelly, L., Vinardell, T., Buckley, C.T., Kelly, D.J Tissue engineering whole bones through endochondral ossification: Regenerating the distal phalanx. Bioresearch Open Access (in press). 5. Gannon, A, Nagel, T., Kelly, D.J. The Changing Role of the Superficial Region in Determining the Dynamic Compressive Properties of Articular Cartilage during Postnatal Development. Osteoarthritis and Cartilage (in press). 6. Almeida, A.V, Cunniffe, G.M., Vinardell, T., Buckley, C.T., O’Brien, F.J., Kelly, D.J. Coupling freshly isolated CD44+ infrapatellar fat pad derived stromal cells with a tgf-β3 eluting cartilage ecm-derived scaffold as a single stage strategy for promoting chondrogenesis. Advanced Healthcare Materials (in press). 7. Gannon, A, Nagel, T., Avery, N., Kelly, D.J. Postnatal changes to the mechanical properties of articular cartilage are driven by the evolution of its collagen network. European Cells and Materials 29: 102-123, 2015. 8. Sheehy, E.S, Mesallati, T., Vinardell, T., Kelly, D.J. Engineering cartilage or endochondral bone: A comparison of different naturally derived hydrogels. Acta Biomaterilia, 13:245-53, 2015. 9. Almeida, H.V., Liu, Y., Cunniffe, G., Buckley, C.T., Matsiko, A., O’Brien, F.J., Kelly, D.J. Controlled release of TGF-β3 from cartilage extra cellular matrix derived scaffolds to promote chondrogenesis of human joint tissue derived stem cells. Acta Biomaterilia, 10(10), 4400-9, 2014. 10. Burke, D., Kelly, D.J. A Mechanobiological Model of Endothelial Cell Migration and Proliferation. Computer Methods in Biomechanics and Biomedical Engineering, 16:1-10, 2014. 11. Steward, A.J., Kelly, D.J., Wagner, D.R. The role of calcium signalling in the chondrogenic response of mesenchymal stem cells to hydrostatic pressure. European Cells and Material, 28, 358-371, 2014. 12. Steward, A.J., Kelly, D.J. Mechanical regulation of mesenchymal stem cell differentiation. Journal of Anatomy, (in press). 13. Liu, Y., Buckley, C.T., Almeida, H.V., Mulhall, K.J., Kelly, D.J. Infrapatellar Fat Pad Derived Stem Cells Maintain Their Chondrogenic Capacity in Disease and can be used to Engineer Cartilaginous Grafts of Clinically Relevant Dimensions. Tissue Engineering, Part A, 20(21-22), 3050-62, 2014. 14. Thompson, E.M., Matsiko, A., Farrell, E., Kelly, D.J., O'Brien, F.J. Recapitulating endochondral ossification: A promising route to in vivo bone regeneration. Journal of Tissue Engineering and Regenerative Medicine (in press). 15. Burke, D., Khayyeri, H., Kelly, D.J. Substrate Stiffness and Oxygen Availability as Regulators of Mesenchymal Stem Cell Differentiation within a Mechanically Loaded Bone Chamber. Biomechanics and Modeling in Mechanobiology, 14(1):93-105, 2014. 16. Sheehy, E.S, Vinardell, T., Toner, M., Buckley, C.T., Kelly, D.J. Altering the architecture of tissue engineered hypertrophic cartilaginous grafts facilitates vascularisation and accelerates mineralisation. PLoS One, 9(3), e90716, 2014. 17. Mesallati, T., Buckley, C.T., Kelly, D.J. Engineering articular cartilage-like grafts by self-assembly of infrapatellar fat pad-derived stem cells. Biotechnology and Bioengineering 111(8), 1686–1698, 2014. 18. Carroll., S., Buckley, C.T., Kelly, D.J. Cyclic Hydrostatic Pressure Promotes A Stable Cartilage Phenotype And Enhances The Functional Development Of Cartilaginous Grafts Engineered Using Multipotent Stromal Cells Isolated From Bone Marrow And Infrapatellar Fat Pad. Journal of Biomechanics 47, (9), 2115-21, 2014. 19. Rolfe, R.A., Nowlan, N.C., Kenny, E.M., Cormican, P., Morris, D.W., Prendergast, P.J., Kelly, D.J. and Murphy, P. Identification of Mechanosensitive Genes during Skeletal Development: Alteration of genes associated with Cytoskeletal Rearrangement and Cell Signalling Pathways. BMC Genomics, 15:48, 2014. 20. Ahearne, M., Liu, Y., Kelly, D.J. Combining freshly isolated chondroprogenitor cells from the infrapatellar fat pad with a growth factor delivery hydrogel as a putative single stage therapy for articular cartilage repair. Tissue Engineering Part A, 20:930-9, 2014. 21. Mesallati, T., Buckley, C.T., Kelly, D.J. A comparison of self-assembly and hydrogel encapsulation as a means to engineer functional cartilaginous grafts using culture expanded chondrocytes. Tissue Engineering, Part C, 20(1):52-63, 2014. 22. Steward, A.J., Wagner, D.R., Kelly, D.J. Exploring the roles of integrin binding and cytoskeletal reorganization during mesenchymal stem cell mechanotransduction in soft and stiff hydrogels subjected to dynamic compression. Journal of the Mechanical Behavior of Biomedical Materials 38:174-82, 2014. 23. Thorpe, S.D., Nagel, T., Carroll, S.F., Kelly, D.J. Modulating gradients in regulatory signals within mesenchymal stem cell seeded hydrogels: A novel strategy to engineer zonal articular cartilage. PLoS One, 8(4): e60764, 2013. 24. Burke, D., Dishowitz, M., Sweetwyne, M., Miedel, E., Hankenson, K.D., Kelly, D.J. The role of oxygen as a regulator of stem cell fate during fracture repair in tsp2-null mice. Journal of Orthopaedic Research, 31(10):1585-96, 2013. 25. Nagel, T., Kelly, D.J. Altering the swelling pressures within in vitro engineered cartilage is predicted to modulate the configuration of the collagen network and hence improve tissue mechanical properties. Journal of the Mechanical Behavior of Biomedical Materials, 22:22-9, 2013. 26. Liu, Y., Buckley, C.T., Mulhall, K.J., Kelly, D.J. Combining BMP-6, TGF-β3 and hydrostatic pressure stimulation enhances the functional development of cartilage tissues engineered using human infrapatellar fat pad derived stem cells. Biomaterials Science, 1, 745-752, 2013. 27. Steward, A.J., Wagner, D.R., Kelly, D.J. The pericellular environment regulates cytoskeletal development and the differentiation of mesenchymal stem cells and determines their response to hydrostatic pressure. European Cells and Materials, 25, 167-178, 2012. 28. Ahearne, M., Kelly, D.J. A comparison of fibrin, agarose and gellan gum hydrogels as carriers of stem cells and growth factor delivery microspheres for cartilage regeneration. Biomedical Materials, 8(3), 035004, 2013. 29. Cilla, M., Pena, E., Martınez, M.A., Kelly, D.J. Comparison of the vulnerability risk for positive versus negative atheroma plaque morphology. Journal of Biomechanics, 46(7):1248-54, 2013. 30. Mesallati, T., Buckley, C.T., Nagel, T., Kelly, D.J. Scaffold architecture determines chondrocyte response to externally applied dynamic compression. Biomechanics and Modeling in Mechanobiology (in press). 31. Sheehy, E., Vinardell, T., Buckley, C.T., Kelly, D.J. Engineering osteochondral constructs through spatial regulation of endochondral ossification. Acta Biomaterialia, 9(3):5484-92, 2013. 32. Nagel, T., Kelly, D.J. The composition of engineered cartilage at the time of implantation determines the likelihood of regenerating tissue with a normal collagen architecture. Tissue Engineering Part A, 19 (7-8), 824-833, 2013. 33. Thorpe, S. D., Steward, A., Buckley, C. T., Kelly, D. J. European Society of Biomechanics S.M. Perren Award 2012: The external mechanical environment can override the influence of local substrate in determining stem cell fate. Journal of Biomechanics, 45(15), 2483–2492, 2012. 34. Haugh, M.G., Thorpe, S.D., Vinardell, T., Buckley, C.T. and Kelly, D.J. The application of plastic compression to modulate fibrin hydrogel mechanical properties. Journal of the Mechanical Behavior of Biomedical Materials, 16:66-72, 2012. 35. Gannon, A., Nagel, T., Kelly, D.J. The role of the superficial region in determining the dynamic properties of articular cartilage. Osteoarthritis and Cartilage, 20 (11), 1417-1425, 2012. 36. O hEireamhoin, S., Buckley, C.T., Jones, E; McGonagle, D., Mulhall, K. J., Kelly, D J. Recapitulating aspects of the oxygen and substrate environment of the damaged joint milieu for stem cell based cartilage tissue engineering. Tissue Engineering Part C, 19(2):117-2, 2013. 37. Burke, D., Kelly, D.J. Substrate Stiffness and Oxygen as Regulators of Stem Cell Differentiation during Tissue Differentiation: A Mechanobiological Model. PLoS One, 7 (7), e40737, 2012. 38. Vinardell, T., Rolfe, R.A., Buckley, C.T., Meyer, E.G., Ahearne, M., Murphy, P., Kelly, D.J. Hydrostatic pressure acts to stabilise a chondrogenic phenotype in porcine joint tissue derived stem cells. e Cells and Materials, 23, 121-34, 2012. 39. Boccaccio, A., Kelly, D.J., Pappalettere, C. A model of tissue differentiation and bone remodelling in fractured vertebrae treated with minimally invasive percutaneous fixation. Medical & Biological Engineering & Computing, 50 (9), 947-959, 2012. 40. Liu, Y., Buckley, C.T., Downey, R., Mulhall, K.J., Kelly, D.J. The role of environmental factors in regulating the development of cartilaginous grafts engineered using osteoarthritic human infrapatellar fat pad derived stem cells. Tissue Engineering Part A, 18(15-16):1531-41, 2012. 41. Vinardell, T., Sheehy, E., Buckley, C.T., Kelly, D.J. A comparison of the functionality and in vivo phenotypic stability of cartilaginous tissues engineered from different stem cells sources. Tissue Engineering Part A, 18(11-12), 1161-1170, 2012. 42. Steward, A.J., Thorpe, S.D., Buckley, C.T., Wagner, D.R., Kelly, D.J. Cell-matrix interactions regulate mesenchymal stem cell response to hydrostatic pressure. Acta Biomaterialia, 8, 2153–2159, 2012. 43. Maher, E., Creane, A., Lally, C. Kelly, D.J. Site Specific Inelasticity of Arterial Tissue. Journal of Biomechanics, 45 (8), 1393-1399, 2012. 44. Maher, E., Creane, A., Lally, C. Kelly, D.J. An anisotropic inelastic constitutive model to describe stress softening and permanent deformation in arterial tissue. Journal of the Mechanical Behavior of Biomedical Materials, 12, 9-19, 2012. 45. Buckley, C.T., Meyer, E.G., Kelly, D.J. The Influence of Construct Scale on the Composition and Functional Properties of Cartilaginous Tissues Engineered Using Bone-Marrow Derived Mesenchymal Stem Cells. Tissue Engineering Part A, 18(3-4), 382-96, 2012. 46. Nagel, T., Kelly, D.J. Apparent behaviour of charged and neutral materials with ellipsoidal fibre distributions and cross-validation of finite element implementations. Journal of the Mechanical Behavior of Biomedical Materials, 9, 122-129, 2012. 47. Sheehy, E., Buckley, C.T., Kelly, D.J. Oxygen Tension Regulates the Osteogenic, Chondrogenic and Endochondral Phenotype of Bone Marrow derived Mesenchymal Stem Cells. Biochemical and Biophysical Research Communications, 417, 305-310, 2012. 48. Buckley, C.T., Kelly, D.J. Expansion in the Presence of FGF-2 Enhances the Functional Development of Cartilaginous Tissues Engineered using Infrapatellar Fat Pad Derived MSCs. Journal of the Mechanical Behavior of Biomedical Materials, 11, 102-111, 2012. 49. Nagel, T., Kelly, D.J. Mechanically induced structural changes during dynamic compression of engineered cartilaginous constructs can potentially explain increases in bulk mechanical properties. Journal of the Royal Society Interface, 9 (69), 777-789, 2012. 50. Haugh, M.G., Meyer, E.G., Thorpe, S.D., Vinardell, T., Duffy, G.P. and Kelly, D.J. Temporal and Spatial Changes in Cartilage-Matrix Specific Gene Expression in Mesenchymal Stem Cells in Response to Dynamic Compression. Tissue Engineering Part A , 17 (23-24), 3085-3093, 2011. 51. Creane, A., Maher, E., Sultan, S., Hynes, N., Kelly, D.J., Lally, C. A remodelling metric for angular fibre distributions and its application to diseased carotid bifurcations. Biomechanics and Modeling in Mechanobiology, 11 (6), 869-882, 2012. 52. Nagel, T., Kelly, D.J. Remodelling of collagen fibre transition stretch and angular distribution in soft biological tissues and cell-seeded hydrogels. Biomechanics and Modeling in Mechanobiology, 11, 325-339, 2012. 53. Ahearne, M., Buckley, C.T., Kelly, D.J. A growth factor delivery system for chondrogenic induction of infrapatellar fat-pad derived stem cells in fibrin hydrogels. Biotechnology and Applied Biochemistry, 58(5), 345-352, 2011. 54. Kasiri, S., Kelly DJ. An Argument for the Use of Multiple Segment Stents in Curved Arteries. Journal of Biomechanical Engineering, 133 (8), 084501, 2011. 55. Early, M., Kelly D.J. The consequences of the mechanical environment of peripheral arteries for nitinol stenting. Medical and Biological Engineering and Computing, 49 (11), 1279-88, 2011 56. Hoey, D.A., Kelly, D.J., Jacobs, C.R. A role for the primary cilium in paracrine signaling between mechanically stimulated osteocytes and mesenchymal stem cells. Biochemical and Biophysical Research Communications, 412 (1), 182-187, 2011. 57. Maher, E., Creane, A., Sultan, S., Hynes, N., Lally, C. Kelly, D.J. Inelasticity of Human Carotid Atherosclerotic Plaque. Annals of Biomedical Engineering, 39(9), 2445-2455, 2011. 58. Meyer, E., Buckley, C.T., Steward, A., Kelly, D.J. The effect of cyclic hydrostatic pressure on the functional development of cartilaginous tissues engineered using bone marrow derived mesenchymal stem cells. Journal of the Mechanical Behavior of Biomedical Materials, 4 (7), 1257-1265, 2011. 59. Cummins, F., O' Reilly, P., Flannery, O., Kelly, D., Kenny, P. Defining the impaction frequency and threshold force required for femoral impaction grafting in revision hip arthroplasty. A human cadaveric mechanical study. Acta Orthopaedica, 82(4), 433-437, 2011. 60. Sheehy, E., Buckley, C.T., Kelly, D.J. Chondrocytes and bone marrow derived mesenchymal stem cells undergoing chondrogenesis in agarose hydrogels of solid and channelled architectures respond differentially to dynamic culture conditions. Journal of Tissue Engineering and Regenerative Medicine, 5(9), 747-758, 2011. 61. Creane, A., Maher, E., Sultan, S., Hynes, N., Kelly, D.J., Lally, C. Prediction of fibre architecture and adaptation in diseased carotid bifurcations. Biomechanics and Modeling in Mechanobiology, 10 (6), 831-843, 2011. 62. Vinardell, T., Buckley, C.T., Thorpe, S.D., Kelly, D.J. Composition-function relations of cartilaginous tissues engineered from chondrocytes and mesenchymal stem cells isolated from bone marrow and infrapatellar fat pad. Journal of Tissue Engineering and Regenerative Medicine, 5(9), 673-683, 2011. 63. Boccaccio, A., Kelly, D.J., Pappalettere, C. A Multi-scale Mechano-Regulation Model of Fracture Repair in Vertebral Bodies. Journal of Orthopaedic Research, 29 (3), 433-443, 2011. 64. Kasiri, S., Kelly, D.J. Taylor, D. Can The Theory of Critical Distances Predict the Failure of Shape Memory Alloys? Computer Methods in Biomechanics and Biomedical Engineering, 14 (6), 491-496, 2011. 65. Buckley, C.T., Vinardell, T., Kelly, D.J. Oxygen Tension Differentially Regulates the Functional Properties of Cartilaginous Tissues Engineered from Infrapatellar Fat Pad Derived MSCs and Articular Chondrocytes. Osteoarthritis and Cartilage, 18 (10), 1345-1354, 2010. 66. Nagel, T., Kelly, D.J. The Influence of Fibre Orientation on the Equilibrium Properties of Neutral and Charged Biphasic Tissues. Journal of Biomechanical Engineering, 132 (11), 114506, 2010. 67. Meyer, E.G., Buckley, C.T., Thorpe, S. D., Kelly, D. J. Low oxygen tension is a more potent promoter of chondrogenic differentiation than dynamic compression. Journal of Biomechanics, 43 (13), 2516-2523, 2010. 68. Thorpe, S. D., Buckley, C. T., Vinardel, T., O’Brien, F. J., Campbell, V. A., Kelly, D. J. The response of bone marrow derived mesenchymal stem cells to dynamic compression following TGF-β3 induced chondrogenic differentiation. Annals of Biomedical Engineering, 38 (9), 2896-2909, 2010. 69. Kelly, D.J. Jacobs, C.R. The Role of Mechanical Signals in Regulating Chondrogenesis and Osteogenesis of Mesenchymal Stem Cells. Birth Defects Research (Part C) 90:75–85 (2010). 70. Zahedmanesh, H., Kelly, D.J., Lally, C. Simulation of a balloon expandable stent in a realistic coronary artery; Determination of the optimum modelling strategy. Journal of Biomechanics, 43 (11) 2126-2132, 2010. 71. Nagel, T., Kelly, D.J. Mechano-regulation of mesenchymal stem cell differentiation and collagen organisation during skeletal tissue repair. Biomechanics and Modeling in Mechanobiology, 9 (3), 359-372, 2010. 72. Partap, S., Plunkett, N.A., Kelly, D.J., O’Brien, F.J. Stimulation of Osteoblasts Using Rest Periods during Bioreactor Culture on Collagen-Glycosaminoglycan Scaffolds. Journal of Material Science: Materials in Medicine, 21(8), 2325-2330, 2010. 73. Boyle, C.J., Lennon, A.B., Early, M., Kelly, D.J., Lally, C., Prendergast, P.J. Computational simulation methodologies for mechanobiological modelling: A cell-centred approach to neointima development in stents. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 368 (1921): 2919-2935, 2010. 74. Buckley, C T; Vinardell, T; Thorpe, S D; Jones, E; McGonagle, D; Kelly, D J. Functional Properties of Cartilaginous Tissues Engineered From Infrapatellar Fat Pad Derived Mesenchymal Stem Cells. Journal of Biomechanics, 43(5): 920-926, 2010. 75. Creane, A., Maher, E., Sultan, S., Hynes, N., Kelly, D.J., Lally, C. Finite element modelling of diseased carotid bifurcations generated from in vivo computerised tomographic angiography. Computers in Biology and Medicine, 40 (4), 419-429, 2010. 76. Early, M., Kelly, D.J. The role of vessel geometry and material properties on the mechanics of stenting in the coronary and peripheral arteries. Proceedings of the Institution of Mechanical Engineers, Part H, Journal of Engineering in Medicine, 224 (3), 465-476, 2010. 77. Vinardell, T; Thorpe, S D; Buckley, C T; Kelly, D J. Chondrogenesis and integration of mesenchymal stem cells within an in vitro cartilage defect repair model. Annals of Biomedical Engineering, 37 (12): 2556-2565, 2009. 78. Maher, E., Creane, A., Sultan, S., Hynes, N., Lally, C. Kelly, D.J. Tensile and compressive properties of fresh human carotid atherosclerotic plaques. Journal of Biomechanics, 42 (16): 2760-2767, 2009. 79. Buckley, C.T., Thorpe, S.D., Kelly, D.J. Engineering of large cartilaginous constructs through the use of microchanneled hydrogels and rotational culture. Tissue Engineering (Part A), 15(11): 3213-3220, 2009. 80. Buckley, C.T., Thorpe, S.D., O’Brien, F.J., Robinson, A.J., Kelly, D.J. The effect of concentration, cooling rate and cell seeding density on the initial mechanical properties of agarose hydrogels. Mechanical Behaviour of Biomedical Materials, 2, 512-521, 2009. 81. Pericevic, I., Lally, C., Toner, D., Kelly, D.J. The influence of plaque composition on underlying arterial wall stress during stent expansion: the case for lesion-specific stents, Medical Engineering and Physics, 31, 428-433, 2009. 82. Jungreuthmayer, C., Jaasma, M.J., Al-Munajjed, A.A., Zanghellini, J., Kelly, D.J., O'Brien, F.J. Deformation simulation of cells seeded on a collagen-GAG scaffold in a flow perfusion bioreactor using a sequential 3D CFD-elastostatics model. Medical Engineering and Physics, 31, 420-427, 2009. 83. Jungreuthmayer, C., Donahue, S.W., Jaasma, M.J., Al-Munajjed, A.A., Zanghellini, J., Kelly, D.J., O'Brien, F.J. A comparative study of shear stresses in collagen-GAG and calcium phosphate scaffolds in bone tissue-engineering bioreactors. Tissue Engineering, 15, 1141-1149, 2009. 84. Early, M., Lally, C., Prendergast, P.J., Kelly, D.J. Stresses in peripheral arteries following stenting: A finite element analysis. Computer Methods in Biomechanics and Biomedical Engineering, 12:1, 25-33, 2009. 85. Thorpe, S. D., Buckley, C. T., Vinardel, T., O’Brien, F. J., Campbell, V. A., Kelly, D. J. Dynamic compression can inhibit chondrogenesis of mesenchymal stem cells. Biochemical and Biophysical Research Communications 337, 458-462, 2008. 86. Boccaccio, A., Prendergast, P.J., Pappalettere, C., Kelly, D.J. Tissue differentiation and bone regeneration in an osteotomized mandible: a computational analysis of the latency period. Medical and Biological Engineering and Computing 46:283-298, 2008. 87. Vard, J., Kelly, D.J., Blayney, A.W., Prendergast, P.J. The influence of ventilation tube design on the magnitude of stress imposed at the implant/tympanic membrane interface. Medical Engineering & Physics, 30, 154-163, 2008. 88. Kelly, D. J., Crawford, A., Dickinson, S.C., Sims, T., Mundy, J., Hollander A. P., Prendergast, P.J, & Hatton, P. V. Biochemical Markers of the Mechanical Quality of Engineered Hyaline Cartilage. Journal of Material Science 18, 273-81, 2007. 89. Boccaccio, A., Pappalettere, C., Kelly, D.J. The influence of expansion rates on mandibular distraction osteogenesis: a computational analysis. Annals of Biomedical Engineering, 35, 1940-60, 2007. 90. Guerin, S., O’Reilly, P., O’Byrne, J., Kelly, D.J. Hydrogen peroxide as a clinical irrigation solution: A comparative study of the effect of hydrogen peroxide versus normal saline on the strength of the bone-cement interface. Biomedical Materials and Engineering 17, 379-86, 2007. 91. Byrne, D. P., Lacroix, D., Kelly, D. J., Plannel, J. A., Prendergast, P. J. Simulation of tissue differentiation in a scaffold as a function of porosity, Young's modulus and dissolution rate: Application of mechanobiological models in tissue engineering. Biomaterials, 28, 5544-54, 2007. 92. Marenzana, M., Kelly, D.J., Prendergast, P.J., Brown, R.A. A collagen-based interface construct for the assessment of cell-dependent mechanical integration of tissue surfaces. Cell and Tissue Research. 327: 293-300, 2007. 93. Kelly, D.J. & Prendergast, P.J. Prediction of the optimal mechanical properties for a scaffold used in osteochondral defect repair. Tissue Engineering 12, 2509-2529, 2006. 94. Kelly, D.J. & Prendergast, P.J. Mechano-regulation of stem cell differentiation and tissue regeneration in osteochondral defects. Journal of Biomechanics, 38, 1413-1422, 2005. 95. Moretti, M., Wendt, D., Dickinson, S.C., Sims, T.J. Hollander, A.P., Kelly, D.J. Prendergast, P.J., Heberer, M., Martin, I. Effects of in vitro pre-culture on the in vivo development of human engineered cartilage in an ectopic model. Tissue Engineering, 11, 1421-1428, 2005. 96. Kelly, D.J. & Prendergast, P.J. Effect of a degraded core on the mechanical behavior of tissue-engineered cartilage constructs: a poro-elastic finite element analysis. Medical & Biological Engineering & Computing, 45, 9-13, 2004. 97. Kelly, D.J., Prendergast, P.J & Blayney, A.W. The effect of prosthesis design on vibration of the reconstructed ossicular chain: a comparative finite element analysis of four prostheses. Otology & Neurotology, 24, 11 – 19, 2003. 98. Kelly, D.J., Blayney, A.W. & Prendergast, P.J. Biomechanics of ossiculoplasty, CME Bulletin Otorhinolaryngology Head and Neck Surgery. 7, 64 – 66, 2003. 99. Prendergast, P.J., Kelly, D.J., Rafferty, M. & Blayney, A.W.. The effect of ventilation tubes on stresses and vibration motion in the tympanic membrane: a finite element analysis, Clinical Otolaryngology and Allied Sciences. 24, 542 – 548, 1999.

Page last modified on June 21, 2015
© 2008-2017 Neural Engineering Group - Trinity College Dublin